Lessons learned to enable question answering on knowledge graphs extracted from scientific publications: A case study on the coronavirus literature.

The article presents a workflow to create a question-answering system whose knowledge base combines knowledge graphs and scientific publications on coronaviruses. It is based on the experience gained in modeling evidence from research articles to provide answers to questions in natural language. The work contains best practices for acquiring scientific publications, tuning language models to identify and normalize relevant entities, creating representational models based on probabilistic topics, and formalizing an ontology that describes the associations between domain concepts supported by the scientific literature. All the resources generated in the domain of coronavirus are available openly as part of the Drugs4COVID initiative, and can be (re)-used independently or as a whole. They can be exploited by scientific communities conducting research related to SARS-CoV-2/COVID-19 and also by therapeutic communities, laboratories, etc., wishing to find and understand relationships between symptoms, drugs, active ingredients and their documentary evidence.

Static Hand Gesture Recognition Using Capacitive Sensing and Machine Learning.

Automated hand gesture recognition is a key enabler of Human-to-Machine Interfaces (HMIs) and smart living. This paper reports the development and testing of a static hand gesture recognition system using capacitive sensing. Our system consists of a 6×18 array of capacitive sensors that captured five gestures-Palm, Fist, Middle, OK, and Index-of five participants to create a dataset of gesture images. The dataset was used to train Decision Tree, Naïve Bayes, Multi-Layer Perceptron (MLP) neural network, and Convolutional Neural Network (CNN) classifiers. Each classifier was trained five times; each time, the classifier was trained using four different participants' gestures and tested with one different participant's gestures. The MLP classifier performed the best, achieving an average accuracy of 96.87% and an average F1 score of 92.16%. This demonstrates that the proposed system can accurately recognize hand gestures and that capacitive sensing is a viable method for implementing a non-contact, static hand gesture recognition system.

Knowledge graph assisted end-to-end medical dialog generation.

Medical dialog systems have the potential to assist e-medicine in improving access to healthcare services, improving patient treatment quality, and lowering medical expenses. In this research, we describe a knowledge-grounded conversation generation model that demonstrates how large-scale medical information in the form of knowledge graphs can aid in language comprehension and generation in medical dialog systems. Generic responses are often produced by existing generative dialog systems, resulting in monotonous and uninteresting conversations. To solve this problem, we combine various pre-trained language models with a medical knowledge base (UMLS) to generate clinically correct and human-like medical conversations using the recently released MedDialog-EN dataset. The medical-specific knowledge graph contains broadly 3 types of medical-related information, including disease, symptom and laboratory test. We perform reasoning over the retrieved knowledge graph by reading the triples in each graph using MedFact attention, which allows us to use semantic information from the graphs for better response generation. In order to preserve medical information, we employ a policy network, which effectively injects relevant entities associated with each dialog into the response. We also study how transfer learning can significantly improve the performance by utilizing a relatively small corpus, created by extending the recently released CovidDialog dataset, containing the dialogs for diseases that are symptoms of Covid-19. Empirical results on the MedDialog corpus and the extended CovidDialog dataset demonstrate that our proposed model significantly outperforms the state-of-the-art methods in terms of both automatic evaluation and human judgment.

Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding.

The search for an effective drug is still urgent for COVID-19 as no drug with proven clinical efficacy is available. Finding the new purpose of an approved or investigational drug, known as drug repurposing, has become increasingly popular in recent years. We propose here a new drug repurposing approach for COVID-19, based on knowledge graph (KG) embeddings. Our approach learns "ensemble embeddings" of entities and relations in a COVID-19 centric KG, in order to get a better latent representation of the graph elements. Ensemble KG-embeddings are subsequently used in a deep neural network trained for discovering potential drugs for COVID-19. Compared to related works, we retrieve more in-trial drugs among our top-ranked predictions, thus giving greater confidence in our prediction for out-of-trial drugs. For the first time to our knowledge, molecular docking is then used to evaluate the predictions obtained from drug repurposing using KG embedding. We show that Fosinopril is a potential ligand for the SARS-CoV-2 nsp13 target. We also provide explanations of our predictions thanks to rules extracted from the KG and instanciated by KG-derived explanatory paths. Molecular evaluation and explanatory paths bring reliability to our results and constitute new complementary and reusable methods for assessing KG-based drug repurposing.

DrugRep-KG: Toward Learning a Unified Latent Space for Drug Repurposing Using Knowledge Graphs.

Drug repurposing or repositioning (DR) refers to finding new therapeutic applications for existing drugs. Current computational DR methods face data representation and negative data sampling challenges. Although retrospective studies attempt to operate various representations, it is a crucial step for an accurate prediction to aggregate these features and bring the associations between drugs and diseases into a unified latent space. In addition, the number of unknown associations between drugs and diseases, which is considered negative data, is much higher than the number of known associations, or positive data, leading to an imbalanced dataset. In this regard, we propose the DrugRep-KG method, which applies a knowledge graph embedding approach for representing drugs and diseases, to address these challenges. Despite the typical DR methods that consider all unknown drug-disease associations as negative data, we select a subset of unknown associations, provided the disease occurs because of an adverse reaction to a drug. DrugRep-KG has been evaluated based on different settings and achieves an AUC-ROC (area under the receiver operating characteristic curve) of 90.83% and an AUC-PR (area under the precision-recall curve) of 90.10%, which are higher than in previous works. Besides, we checked the performance of our framework in finding potential drugs for coronavirus infection and skin-related diseases: contact dermatitis and atopic eczema. DrugRep-KG predicted beclomethasone for contact dermatitis, and fluorometholone, clocortolone, fluocinonide, and beclomethasone for atopic eczema, all of which have previously been proven to be effective in other studies. Fluorometholone for contact dermatitis is a novel suggestion by DrugRep-KG that should be validated experimentally. DrugRep-KG also predicted the associations between COVID-19 and potential treatments suggested by DrugBank, in addition to new drug candidates provided with experimental evidence. The data and code underlying this article are available at https://github.com/CBRC-lab/DrugRep-KG.

The impact of COVID-19 on online medical education: a knowledge graph analysis based on co-term analysis.

BACKGROUND: This study aims to identify the characteristics and future directions of online medical education in the context of the novel coronavirus outbreak new through visual analytics using CiteSpace and VOSviewer bibliometric methods. METHOD: From Web of Science, we searched for articles published between 2020 and 2022 using the terms online education, medical education and COVID-19, ended up with 2555 eligible papers, and the articles published between 2010 and 2019 using the terms online education, medical education and COVID-19, and we ended up with 4313 eligible papers. RESULTS: Before the COVID-19 outbreak, Medical students and care were the most frequent keywords and the most cited author was BRENT THOMA with 18 times. The United States is the country with the greatest involvement and research impact in the field of online medical education. The most cited journal is ACAD MED with 1326 citations. After the COVID-19 outbreak, a surge in the number of research results in related fields, and ANXIETY and four secondary keywords were identified. In addition, the concentration of authors of these publications in the USA and China is a strong indication that local epidemics and communication technologies have influenced the development of online medical education research. Regarding the centrality of research institutions, the most influential co-author network is Harvard Medical School in the United States; and regarding the centrality of references, the most representative journal to which it belongs is VACCINE. CONCLUSION: This study found that hey information such as keywords, major institutions and authors, and countries differ in the papers before and after the COVID-19 outbreak. The novel coronavirus outbreak had a significant impact on the online education aspect. For non-medical and medical students, the pandemic has led to home isolation, making it difficult to offer face-to-face classes such as laboratory operations. Students have lost urgency and control over the specifics of face-to-face instruction, which has reduced the quality of teaching. Therefore, we should improve our education model according to the actual situation to ensure the quality of teaching while taking into account the physical and psychological health of students.

PrivacyMask: Real-world privacy protection in face ID systems.

Recent works have illustrated that many facial privacy protection methods are effective in specific face recognition algorithms. However, the COVID-19 pandemic has promoted the rapid innovation of face recognition algorithms for face occlusion, especially for the face wearing a mask. It is tricky to avoid being tracked by artificial intelligence only through ordinary props because many facial feature extractors can determine the ID only through a tiny local feature. Therefore, the ubiquitous high-precision camera makes privacy protection worrying. In this paper, we establish an attack method directed against liveness detection. A mask printed with a textured pattern is proposed, which can resist the face extractor optimized for face occlusion. We focus on studying the attack efficiency in adversarial patches mapping from two-dimensional to three-dimensional space. Specifically, we investigate a projection network for the mask structure. It can convert the patches to fit perfectly on the mask. Even if it is deformed, rotated and the lighting changes, it will reduce the recognition ability of the face extractor. The experimental results show that the proposed method can integrate multiple types of face recognition algorithms without significantly reducing the training performance. If we combine it with the static protection method, people can prevent face data from being collected.

Knowledge graph of wastewater-based epidemiology development: A data-driven analysis based on research topics and trends.

Wastewater-based epidemiology (WBE) has contributed significantly to the monitoring of drug use and transmission of viruses that has been published in numerous research papers. In this paper, we used LitStraw, a self-developed text extraction tool, to extract, analyze, and construct knowledge graphs from nearly 900 related papers in PDF format collected in Web of Science from 2000 to 2021 to analyze the research hotspots and development trends of WBE. The results showed a growing number of WBE publications in multidisciplinary cross-collaboration, with more publications and close collaboration between the USA, Australia, China, and European countries. The keywords of illicit drugs and pharmaceuticals still maintain research hotness, but the specific research hotspots change significantly, among which the research hotspots of new psychoactive substances, biomarkers, and stability show an increasing trend. In addition, judging the spread of COVID-19 by the presence of SARS-CoV-2 RNA in sewage has become the focus since 2020. This work can show the development of WBE more clearly by constructing a knowledge graph and also provide new ideas for the paper mining analysis methods in different fields.

Extraction of knowledge graph of Covid-19 through mining of unstructured biomedical corpora.

The number of biomedical articles published is increasing rapidly over the years. Currently there are about 30 million articles in PubMed and over 25 million mentions in Medline. Among these fundamentals, Biomedical Named Entity Recognition (BioNER) and Biomedical Relation Extraction (BioRE) are the most essential in analysing the literature. In the biomedical domain, Knowledge Graph is used to visualize the relationships between various entities such as proteins, chemicals and diseases. Scientific publications have increased dramatically as a result of the search for treatments and potential cures for the new Coronavirus, but efficiently analysing, integrating, and utilising related sources of information remains a difficulty. In order to effectively combat the disease during pandemics like COVID-19, literature must be used quickly and effectively. In this paper, we introduced a fully automated framework consists of BERT-BiLSTM, Knowledge graph, and Representation Learning model to extract the top diseases, chemicals, and proteins related to COVID-19 from the literature. The proposed framework uses Named Entity Recognition models for disease recognition, chemical recognition, and protein recognition. Then the system uses the Chemical - Disease Relation Extraction and Chemical - Protein Relation Extraction models. And the system extracts the entities and relations from the CORD-19 dataset using the models. The system then creates a Knowledge Graph for the extracted relations and entities. The system performs Representation Learning on this KG to get the embeddings of all entities and get the top related diseases, chemicals, and proteins with respect to COVID-19.

A biomedical knowledge graph-based method for drug-drug interactions prediction through combining local and global features with deep neural networks.

Drug-drug interactions (DDIs) prediction is a challenging task in drug development and clinical application. Due to the extremely large complete set of all possible DDIs, computer-aided DDIs prediction methods are getting lots of attention in the pharmaceutical industry and academia. However, most existing computational methods only use single perspective information and few of them conduct the task based on the biomedical knowledge graph (BKG), which can provide more detailed and comprehensive drug lateral side information flow. To this end, a deep learning framework, namely DeepLGF, is proposed to fully exploit BKG fusing local-global information to improve the performance of DDIs prediction. More specifically, DeepLGF first obtains chemical local information on drug sequence semantics through a natural language processing algorithm. Then a model of BFGNN based on graph neural network is proposed to extract biological local information on drug through learning embedding vector from different biological functional spaces. The global feature information is extracted from the BKG by our knowledge graph embedding method. In DeepLGF, for fusing local-global features well, we designed four aggregating methods to explore the most suitable ones. Finally, the advanced fusing feature vectors are fed into deep neural network to train and predict. To evaluate the prediction performance of DeepLGF, we tested our method in three prediction tasks and compared it with state-of-the-art models. In addition, case studies of three cancer-related and COVID-19-related drugs further demonstrated DeepLGF's superior ability for potential DDIs prediction. The webserver of the DeepLGF predictor is freely available at http://120.77.11.78/DeepLGF/.

Multiview Incomplete Knowledge Graph Integration with application to cross-institutional EHR data harmonization.

OBJECTIVE: The growing availability of electronic health records (EHR) data opens opportunities for integrative analysis of multi-institutional EHR to produce generalizable knowledge. A key barrier to such integrative analyses is the lack of semantic interoperability across different institutions due to coding differences. We propose a Multiview Incomplete Knowledge Graph Integration (MIKGI) algorithm to integrate information from multiple sources with partially overlapping EHR concept codes to enable translations between healthcare systems. METHODS: The MIKGI algorithm combines knowledge graph information from (i) embeddings trained from the co-occurrence patterns of medical codes within each EHR system and (ii) semantic embeddings of the textual strings of all medical codes obtained from the Self-Aligning Pretrained BERT (SAPBERT) algorithm. Due to the heterogeneity in the coding across healthcare systems, each EHR source provides partial coverage of the available codes. MIKGI synthesizes the incomplete knowledge graphs derived from these multi-source embeddings by minimizing a spherical loss function that combines the pairwise directional similarities of embeddings computed from all available sources. MIKGI outputs harmonized semantic embedding vectors for all EHR codes, which improves the quality of the embeddings and enables direct assessment of both similarity and relatedness between any pair of codes from multiple healthcare systems. RESULTS: With EHR co-occurrence data from Veteran Affairs (VA) healthcare and Mass General Brigham (MGB), MIKGI algorithm produces high quality embeddings for a variety of downstream tasks including detecting known similar or related entity pairs and mapping VA local codes to the relevant EHR codes used at MGB. Based on the cosine similarity of the MIKGI trained embeddings, the AUC was 0.918 for detecting similar entity pairs and 0.809 for detecting related pairs. For cross-institutional medical code mapping, the top 1 and top 5 accuracy were 91.0% and 97.5% when mapping medication codes at VA to RxNorm medication codes at MGB; 59.1% and 75.8% when mapping VA local laboratory codes to LOINC hierarchy. When trained with 500 labels, the lab code mapping attained top 1 and 5 accuracy at 77.7% and 87.9%. MIKGI also attained best performance in selecting VA local lab codes for desired laboratory tests and COVID-19 related features for COVID EHR studies. Compared to existing methods, MIKGI attained the most robust performance with accuracy the highest or near the highest across all tasks. CONCLUSIONS: The proposed MIKGI algorithm can effectively integrate incomplete summary data from biomedical text and EHR data to generate harmonized embeddings for EHR codes for knowledge graph modeling and cross-institutional translation of EHR codes.

Construction and application of COVID-19 infectors activity information knowledge graph.

During COVID-19 prevention and control, people need to be aware of the outbreak situation in their area to avoid being inconvenienced by the outbreak and even becoming infected. Thus, this project constructs a knowledge graph with COVID-19 infector activity information, by using the official flow information of the infected people from the provincial and municipal websites. This knowledge graph is the basis of the COVID-19 applications for tracing, visualization and reporting proposes. In the implementation process, we (1) collect a dataset with the information on COVID-19 cases from the prevention and control centers, (2) extract the entity elements with a Bert + BILSTM + CRF-based model, and (3) pre-process the dataset and construct a knowledge graph with manual annotation and human-based review. Finally, we use the knowledge graph to develop a web-based application to implement the question and answer, query, transmission path tracking and the "No.0" tracing infector functions.

A Knowledge Graph of Mechanistic Associations Between COVID-19, Diabetes Mellitus, and Chronic Kidney Disease.

We present an automated knowledge synthesis and discovery framework to analyze published literature to identify and represent underlying mechanistic associations that aggravate chronic conditions due to COVID-19. Our literature-based discovery approach integrates text mining, knowledge graphs and medical ontologies to discover hidden and previously unknown pathophysiologic relations, dispersed across multiple public literature databases, between COVID-19 and chronic disease mechanisms. We applied our approach to discover mechanistic associations between COVID-19 and chronic conditions-i.e. diabetes mellitus and chronic kidney disease-to understand the long-term impact of COVID-19 on patients with chronic diseases. We found several gene-disease associations that could help identify mechanisms driving poor outcomes for COVID-19 patients with underlying conditions.

Deep Denoising of Raw Biomedical Knowledge Graph From COVID-19 Literature, LitCovid, and Pubtator: Framework Development and Validation.

BACKGROUND: Multiple types of biomedical associations of knowledge graphs, including COVID-19-related ones, are constructed based on co-occurring biomedical entities retrieved from recent literature. However, the applications derived from these raw graphs (eg, association predictions among genes, drugs, and diseases) have a high probability of false-positive predictions as co-occurrences in the literature do not always mean there is a true biomedical association between two entities. OBJECTIVE: Data quality plays an important role in training deep neural network models; however, most of the current work in this area has been focused on improving a model's performance with the assumption that the preprocessed data are clean. Here, we studied how to remove noise from raw knowledge graphs with limited labeled information. METHODS: The proposed framework used generative-based deep neural networks to generate a graph that can distinguish the unknown associations in the raw training graph. Two generative adversarial network models, NetGAN and Cross-Entropy Low-rank Logits (CELL), were adopted for the edge classification (ie, link prediction), leveraging unlabeled link information based on a real knowledge graph built from LitCovid and Pubtator. RESULTS: The performance of link prediction, especially in the extreme case of training data versus test data at a ratio of 1:9, demonstrated that the proposed method still achieved favorable results (area under the receiver operating characteristic curve >0.8 for the synthetic data set and 0.7 for the real data set), despite the limited amount of testing data available. CONCLUSIONS: Our preliminary findings showed the proposed framework achieved promising results for removing noise during data preprocessing of the biomedical knowledge graph, potentially improving the performance of downstream applications by providing cleaner data.

A knowledge graph embedding based approach to predict the adverse drug reactions using a deep neural network.

Recently Artificial Intelligence(AI) has not only been used to diagnose the disease but also to cure the disease. Researchers started using AI for drug discovery. Predicting the Adverse Drug Reactions(ADRs) caused by the drug in the manufacturing stage or in the clinical trial stage is a very important problem in drug discovery. ADRs have become a major concern resulting in injuries and also becoming fatal sometimes. Drug safety has gained much importance over the years propelling to the forefront investigation of predicting the ADRs. Although prior studies have queried diverse approaches to predict ADRs, very few were found to be effective. Also, the problem of having fewer reports makes the prediction of ADRs more difficult. To tackle this problem effectively, a novel method has been proposed in this paper. The proposed method is based on Knowledge Graph(KG) embedding. Using the KG embedding, we designed and trained a custom-made Deep Neural Network(DNN) called KGDNN(Knowledge Graph DNN) for predicting the ADRs. A KG has been constructed with 6 types of entities: drugs, ADRs, target proteins, indications, pathways, and genes. Using the Node2Vec algorithm, each node has been embedded into a feature space. Using those embeddings, the ADRs are classified by the KGDNN model. The proposed method has obtained an AUROC score of 0.917 and significantly outperformed the existing methods. Two case studies on drugs causing liver injury and COVID-19 recommended drugs have been performed to illustrate the model efficacy.

Expediting knowledge acquisition by a web framework for Knowledge Graph Exploration and Visualization (KGEV): case studies on COVID-19 and Human Phenotype Ontology.

BACKGROUND: Knowledges graphs (KGs) serve as a convenient framework for structuring knowledge. A number of computational methods have been developed to generate KGs from biomedical literature and use them for downstream tasks such as link prediction and question answering. However, there is a lack of computational tools or web frameworks to support the exploration and visualization of the KG themselves, which would facilitate interactive knowledge discovery and formulation of novel biological hypotheses. METHOD: We developed a web framework for Knowledge Graph Exploration and Visualization (KGEV), to construct and visualize KGs in five stages: triple extraction, triple filtration, metadata preparation, knowledge integration, and graph database preparation. The application has convenient user interface tools, such as node and edge search and filtering, data source filtering, neighborhood retrieval, and shortest path calculation, that work by querying a backend graph database. Unlike other KGs, our framework allows fast retrieval of relevant texts supporting the relationships in the KG, thus allowing human reviewers to judge the reliability of the knowledge extracted. RESULTS: We demonstrated a case study of using the KGEV framework to perform research on COVID-19. The COVID-19 pandemic resulted in an explosion of relevant literature, making it challenging to make full use of the vast and heterogenous sources of information. We generated a COVID-19 KG with heterogenous information, including literature information from the CORD-19 dataset, as well as other existing knowledge from eight data sources. We showed the utility of KGEV in three intuitive case studies to explore and query knowledge on COVID-19. A demo of this web application can be accessed at http://covid19nlp.wglab.org . Finally, we also demonstrated a turn-key adaption of the KGEV framework to study clinical phenotypic presentation of human diseases by Human Phenotype Ontology (HPO), illustrating the versatility of the framework. CONCLUSION: In an era of literature explosion, the KGEV framework can be applied to many emerging diseases to support structured navigation of the vast amount of newly published biomedical literature and other existing biological knowledge in various databases. It can be also used as a general-purpose tool to explore and query gene-phenotype-disease-drug relationships interactively.

Research Trends around Exercise Rehabilitation among Cancer Patients: A Bibliometrics and Visualized Knowledge Graph Analysis.

This study analyzed the research hotspots and frontiers of exercise rehabilitation among cancer patients via CiteSpace. Relevant literature published in the core collection of the Web of Science (WoS) database from January 1, 2000, to February 6, 2022, was searched. Further, we used CiteSpace5.8R1 to generate a network map and identified top authors, institutions, countries, keywords, and research trends. A total of 2706 related literature were retrieved. The most prolific writer was found to be Kathryn H Schmitz (21 articles). The University of Toronto (64 articles) was found to be the leading institution, with the United States being the leading country. Further, "rehabilitation," "exercise," "quality of life," "cancer," and "physical activity" were the top 5 keywords based on frequency; next, "disability," "survival," "fatigue," "cancer," and "rehabilitation" were the top 5 keywords based on centrality. The keyword "fatigue" was ranked at the top of the most cited list. Finally, "rehabilitation medicine," "activities of daily living," "lung neoplasm," "implementation," "hospice," "exercise oncology," "mental health," "telemedicine," and "multidisciplinary" are potential topics for future research. Our results show that the research hotspots have changed from "quality of life," "survival," "rehabilitation," "exercise," "cancer," "physical therapy," "fatigue," and "breast cancer" to "exercise oncology," "COVID-19," "rehabilitation medicine," "inpatient rehabilitation," "implementation," "telemedicine," "lung neoplasm," "telehealth," "multidisciplinary," "psycho-oncology," "hospice," "adapted physical activity," "cancer-related symptom," "cognitive function," and "behavior maintenance." Future research should explore the recommended dosage and intensity of exercise in cancer patients. Further, following promotion of the concept of multidisciplinary cooperation and the rapid development of Internet medical care, a large amount of patient data has been accumulated; thus, how to effectively use this data to generate results of high clinical value is a question for future researchers.

Internet of Things with Deep Learning-Based Face Recognition Approach for Authentication in Control Medical Systems.

Internet of Things (IoT) with deep learning (DL) is drastically growing and plays a significant role in many applications, including medical and healthcare systems. It can help users in this field get an advantage in terms of enhanced touchless authentication, especially in spreading infectious diseases like coronavirus disease 2019 (COVID-19). Even though there is a number of available security systems, they suffer from one or more of issues, such as identity fraud, loss of keys and passwords, or spreading diseases through touch authentication tools. To overcome these issues, IoT-based intelligent control medical authentication systems using DL models are proposed to enhance the security factor of medical and healthcare places effectively. This work applies IoT with DL models to recognize human faces for authentication in smart control medical systems. We use Raspberry Pi (RPi) because it has low cost and acts as the main controller in this system. The installation of a smart control system using general-purpose input/output (GPIO) pins of RPi also enhanced the antitheft for smart locks, and the RPi is connected to smart doors. For user authentication, a camera module is used to capture the face image and compare them with database images for getting access. The proposed approach performs face detection using the Haar cascade techniques, while for face recognition, the system comprises the following steps. The first step is the facial feature extraction step, which is done using the pretrained CNN models (ResNet-50 and VGG-16) along with linear binary pattern histogram (LBPH) algorithm. The second step is the classification step which can be done using a support vector machine (SVM) classifier. Only classified face as genuine leads to unlock the door; otherwise, the door is locked, and the system sends a notification email to the home/medical place with detected face images and stores the detected person name and time information on the SQL database. The comparative study of this work shows that the approach achieved 99.56% accuracy compared with some different related methods.

Knowledge graph analysis and visualization of AI technology applied in COVID-19.

With the global outbreak of coronavirus disease (COVID-19) all over the world, artificial intelligence (AI) technology is widely used in COVID-19 and has become a hot topic. In recent 2 years, the application of AI technology in COVID-19 has developed rapidly, and more than 100 relevant papers are published every month. In this paper, we combined with the bibliometric and visual knowledge map analysis, used the WOS database as the sample data source, and applied VOSviewer and CiteSpace analysis tools to carry out multi-dimensional statistical analysis and visual analysis about 1903 pieces of literature of recent 2 years (by the end of July this year). The data is analyzed by several terms with the main annual article and citation count, major publication sources, institutions and countries, their contribution and collaboration, etc. Since last year, the research on the COVID-19 has sharply increased; especially the corresponding research fields combined with the AI technology are expanding, such as medicine, management, economics, and informatics. The China and USA are the most prolific countries in AI applied in COVID-19, which have made a significant contribution to AI applied in COVID-19, as the high-level international collaboration of countries and institutions is increasing and more impactful. Moreover, we widely studied the issues: detection, surveillance, risk prediction, therapeutic research, virus modeling, and analysis of COVID-19. Finally, we put forward perspective challenges and limits to the application of AI in the COVID-19 for researchers and practitioners to facilitate future research on AI applied in COVID-19.

Key factors affecting people's unwillingness to be confined during the COVID-19 pandemic in Spain: a large-scale population study.

Population confinements have been one of the most widely adopted non-pharmaceutical interventions (NPIs) implemented by governments across the globe to help contain the spread of the SARS-CoV-2 virus. While confinement measures have been proven to be effective to reduce the number of infections, they entail significant economic and social costs. Thus, different policy makers and social groups have exhibited varying levels of acceptance of this type of measures. In this context, understanding the factors that determine the willingness of individuals to be confined during a pandemic is of paramount importance, particularly, to policy and decision-makers. In this paper, we study the factors that influence the unwillingness to be confined during the COVID-19 pandemic by the means of a large-scale, online population survey deployed in Spain. We perform two types of analyses (logistic regression and automatic pattern discovery) and consider socio-demographic, economic and psychological factors, together with the 14-day cumulative incidence per 100,000 inhabitants. Our analysis of 109,515 answers to the survey covers data spanning over a 5-month time period to shed light on the impact of the passage of time. We find evidence of pandemic fatigue as the percentage of those who report an unwillingness to be in confinement increases over time; we identify significant gender differences, with women being generally less likely than men to be able to sustain long-term confinement of at least 6 months; we uncover that the psychological impact was the most important factor to determine the willingness to be in confinement at the beginning of the pandemic, to be replaced by the economic impact as the most important variable towards the end of our period of study. Our results highlight the need to design gender and age specific public policies, to implement psychological and economic support programs and to address the evident pandemic fatigue as the success of potential future confinements will depend on the population's willingness to comply with them.